Supportive management strategies for disseminated intravascular coagulation
نویسندگان
چکیده
Disseminated intravascular coagulation (DIC) is a syndrome characterised by the systemic activation of blood coagulation, which generates intravascular fibrin leading to thrombosis of smalland medium-sized vessels and eventually contributes to organ dysfunction (1). In addition, the consumption of platelets and coagulation factors may predispose patients with DIC to haemorrhagic complications. There is no gold standard for the diagnosis of DIC and no single test that confirms the diagnosis. Thus, the presence of underlying conditions known to cause DIC, clinical symptoms and signs together with laboratory assays including coagulation assays and blood count may allow clinicians to diagnose DIC. Blood tests have been combined in diagnostic scoring systems to aid diagnosis (2, 3). DIC has been further subdivided into “non-overt DIC”, a term used when the haemostatic system is stressed but compensated, and “overt DIC” when the haemostatic system is stressed and decompensated. Non-overt DIC represents a subtle haemostatic dysfunction, while overt DIC is often associated with clinical consequences. Recently, it has been proposed to categorise DIC into four clinical types, i. e. bleeding, organ failure, massive bleeding, and Supportive management strategies for disseminated intravascular coagulation
منابع مشابه
Pathogenesis, diagnosis, and management of disseminated intravascular coagulation: a literature review.
BACKGROUND Disseminated Intravascular Coagulation (DIC) is an acquired syndrome characterized by systemic intravascular activation of coagulation, leading to deposition of fibrin in the circulation, occurring in the course of severe diseases. OBJECTIVE To review literature for articles that focus on the pathogenesis, diagnosis, and management of DIC. INFORMATION SOURCES Selected articles fr...
متن کاملDisseminated Intravascular Coagulation in a Case of Brucellosis Misdiagnosed as Thrombotic Thrombocytopenia Purpura
متن کامل
Plasma Fibrinogen and D-dimer in Children With Sepsis: A Single-center Experience
Background & Objectives: In sepsis, enhanced fibrin formation, impaired fibrin degradation, and intravascular fibrin deposition lead to a prothrombotic state. The current study aimed at measuring various coagulation parameters to predict an early marker for disseminated intravascular coagulation (DIC). Methods: The current prospective s...
متن کاملCoagulation abnormalities in critically ill patients
Many critically ill patients develop hemostatic abnormalities, ranging from isolated thrombocytopenia or prolonged global clotting tests to complex defects, such as disseminated intravascular coagulation. There are many causes for a deranged coagulation in critically ill patients and each of these underlying disorders may require specific therapeutic or supportive management. In recent years, n...
متن کاملUnderstanding and treating solid tumor–related disseminated intravascular coagulation in the “era” of targeted cancer therapies
A systemic activation of blood coagulation is usually present in many clinical conditions including the infectious or inflammatory ones and malignant disease as well. Depending upon circumstances, patients suffering from acute decompensated disseminated intravascular coagulation may be managed by a medical oncologist and either an internist or a physician working in an emergency and/or intensiv...
متن کامل